ETB Receptor in Renal Medulla Is Enhanced by Local Sodium During Low Salt Intake

Renal endothelin-1 participates in sodium and water handling, and its urinary excretion is increased in sodium-retentive states. We compared the cortical and medullary renal expression of prepro-endothelin-1, endothelin-converting enzyme-1, and endothelin type A and type B receptors in patients who...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-08, Vol.40 (2), p.179-185
Main Authors: Vanni, Simone, Polidori, Gianluca, Cecioni, Ilaria, Serni, Sergio, Carini, Marco, Modesti, Pietro Amedeo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
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Summary:Renal endothelin-1 participates in sodium and water handling, and its urinary excretion is increased in sodium-retentive states. We compared the cortical and medullary renal expression of prepro-endothelin-1, endothelin-converting enzyme-1, and endothelin type A and type B receptors in patients who underwent nephrectomy after normal (108 mmol/d NaCl; n=6) or low (20 mmol/d NaCl; n=6) sodium diet and investigated whether sodium exerts a direct role on endothelin receptor binding in vitro. With normal sodium diet prepro-endothelin-1 mRNA was 3-fold higher in renal medulla than in cortex (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000026809.68674.F9