Muscle regeneration during hindlimb unloading results in a reduction in muscle size after reloading

1  Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27695; and 2  Department of Anatomy, University of Wisconsin Medical School, Madison, Wisconsin 53706 The hindlimb-unloading model was used to study the ability of muscle injured in a weightless environment to...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2001-07, Vol.91 (1), p.183-190
Main Authors: Mozdziak, P. E, Pulvermacher, P. M, Schultz, E
Format: Article
Language:English
Subjects:
Aerospace Medicine
Animals
Biological and medical sciences
Cell Nucleus - ultrastructure
Cells
Deoxyribonucleic acid
DNA
DNA - genetics
Fundamental and applied biological sciences. Psychology
Hindlimb Suspension
Male
Mitosis
Muscle Development
Muscle, Skeletal - anatomy & histology
Muscle, Skeletal - cytology
Muscle, Skeletal - growth & development
Muscle, Skeletal - physiology
Muscular system
Organ Size
Rats
Rats, Sprague-Dawley
Regeneration - physiology
Size
Space life sciences
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:1  Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27695; and 2  Department of Anatomy, University of Wisconsin Medical School, Madison, Wisconsin 53706 The hindlimb-unloading model was used to study the ability of muscle injured in a weightless environment to recover after reloading. Satellite cell mitotic activity and DNA unit size were determined in injured and intact soleus muscles from hindlimb-unloaded and age-matched weight-bearing rats at the conclusion of 28 days of hindlimb unloading, 2 wk after reloading, and 9 wk after reloading. The body weights of hindlimb-unloaded rats were significantly ( P   0.05) as those of weight-bearing rats 2 and 9 wk after reloading. The soleus muscle weight, soleus muscle weight-to-body weight ratio, myofiber diameter, number of nuclei per millimeter, and DNA unit size were significantly ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2001.91.1.183