Parahydrogen-induced polarization in imaging: Subsecond 13C angiography

High nuclear spin polarization of 13C was reached in organic molecules. Enhancements of up to 104, compared to thermal polarization at 1.5 T, were achieved using the parahydrogen‐induced polarization technique in combination with a field cycling method. While parahydrogen has no net polarization, it...

Full description

Saved in:
Bibliographic Details
Published in:Magnetic resonance in medicine 2001-07, Vol.46 (1), p.1-5
Main Authors: Golman, K., Axelsson, O., Jóhannesson, H., Månsson, S., Olofsson, C., Petersson, J.S.
Format: Article
Language:English
Subjects:
angiography
Biological and medical sciences
diabatic
hyperpolarized 13C
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
parahydrogen-induced polarization
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High nuclear spin polarization of 13C was reached in organic molecules. Enhancements of up to 104, compared to thermal polarization at 1.5 T, were achieved using the parahydrogen‐induced polarization technique in combination with a field cycling method. While parahydrogen has no net polarization, it has a high spin order, which is retained when hydrogen is incorporated into another molecule by a chemical reaction. By subjecting this molecule to a sudden change of the external magnetic field, the spin order is transferred into net polarization. A 13C angiogram of an animal was generated in less than a second. Magn Reson Med 46:1–5, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.1152