Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats

In our previous study, fish protein was proven to reduce serum lipids and body fat accumulation by skeletal muscle hypertrophy and enhancing basal energy expenditure in rats. In the present study, we examined the precise effects of fish protein intake on different skeletal muscle fiber types and met...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2015-01, Vol.79 (1), p.109-116
Main Authors: Kawabata, Fuminori, Mizushige, Takafumi, Uozumi, Keisuke, Hayamizu, Kohsuke, Han, Li, Tsuji, Tomoko, Kishida, Taro
Format: Article
Language:English
Subjects:
Adipose Tissue - drug effects
Animals
Blood Glucose - drug effects
Blood Glucose - metabolism
Body Weight - drug effects
Carnitine O-Palmitoyltransferase - genetics
Carnitine O-Palmitoyltransferase - metabolism
Caseins - administration & dosage
Caseins - metabolism
Dietary Proteins - administration & dosage
Dietary Proteins - metabolism
Energy Metabolism
fish protein
Fish Proteins - administration & dosage
Fish Proteins - metabolism
Fishes - metabolism
Gene Expression Regulation
Glucose Transporter Type 4 - genetics
Glucose Transporter Type 4 - metabolism
Hypertrophy - chemically induced
Hypertrophy - metabolism
Hypertrophy - pathology
Insulin Resistance
Liver - drug effects
Liver - metabolism
Male
muscle fiber type
Muscle Fibers, Fast-Twitch - drug effects
Muscle Fibers, Fast-Twitch - metabolism
Muscle Fibers, Slow-Twitch - drug effects
Muscle Fibers, Slow-Twitch - metabolism
Myosin Heavy Chains - genetics
Myosin Heavy Chains - metabolism
Peroxisome Proliferator-Activated Receptors - genetics
Peroxisome Proliferator-Activated Receptors - metabolism
Rats
Rats, Sprague-Dawley
skeletal muscle
Triglycerides - metabolism
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Summary:In our previous study, fish protein was proven to reduce serum lipids and body fat accumulation by skeletal muscle hypertrophy and enhancing basal energy expenditure in rats. In the present study, we examined the precise effects of fish protein intake on different skeletal muscle fiber types and metabolic gene expression of the muscle. Fish protein increased fast-twitch muscle weight, reduced liver triglycerides and serum glucose levels, compared with the casein diet after 6 or 8 weeks of feeding. Furthermore, fish protein upregulated the gene expressions of a fast-twitch muscle-type marker and a glucose transporter in the muscle. These results suggest that fish protein induces fast-muscle hypertrophy, and the enhancement of basal energy expenditure by muscle hypertrophy and the increase in muscle glucose uptake reduced liver lipids and serum glucose levels. The present results also imply that fish protein intake causes a slow-to-fast shift in muscle fiber type. Fish protein intake for 8 weeks induced fast-muscle hypertrophy and upregulated expression of fast-muscle related genes in rats.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2014.951025