A compact gamma camera for biological imaging

A compact gamma camera for biological imaging

A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 46 mm /spl times/ 96 mm. Two flat-panel Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs) are coupled to a pixellated NaI(Tl) scintillator which views the animal...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on nuclear science 2006-02, Vol.53 (1), p.59-65
Main Authors: Bradley, E.L., Cella, J., Majewski, S., Popov, V., Jianguo Qian, Saha, M.S., Smith, M.F., Weisenberger, A.G., Welsh, R.E.
Format: Article
Language:eng
Subjects:
Animals
Biomedical imaging
Cameras
Collection
Collimators
DESIGN
Detectors
GAMMA CAMERAS
Image edge detection
Imaging
IN VIVO
IODINE 125
MICE
Optical collimators
Optical coupling
Optical imaging
Photomultiplier tubes
Photomultipliers
Position sensitive particle detectors
RADIOLOGY AND NUCLEAR MEDICINE
RESOLUTION
scintillation detectors
SENSITIVITY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
small animal imaging
Solid scintillation detectors
Tubes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 46 mm /spl times/ 96 mm. Two flat-panel Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs) are coupled to a pixellated NaI(Tl) scintillator which views the animal through a copper-beryllium (CuBe) parallel-hole collimator specially designed for /sup 125/I. Although the PSPMTs have insensitive areas at their edges and there is a physical gap, corrections for scintillation light collection at the junction between the two tubes results in a uniform response across the entire rectangular area of the detector. The system described has been developed to optimize both sensitivity and resolution for in-vivo imaging of small animals injected with iodinated compounds. We demonstrate an in-vivo application of this detector, particularly to SPECT, by imaging mice injected with approximately 10-15 /spl mu/Ci of /sup 125/I.
ISSN:0018-9499
1558-1578