Volume-based glucose metabolic analysis of FDG PET/CT: The optimum threshold and conditions to suppress physiological myocardial uptake

FDG PET/CT plays a significant role in the diagnosis of inflammatory heart diseases and cardiac tumors. We attempted to determine the optimal FDG uptake threshold for volume-based analyses and to evaluate the relationship between the myocardial physiological uptake volume in FDG PET and several clin...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nuclear cardiology 2019-06, Vol.26 (3), p.909-918
Main Authors: Manabe, Osamu, Kroenke, Markus, Aikawa, Tadao, Murayama, Atsuto, Naya, Masanao, Masuda, Atsuro, Oyama-Manabe, Noriko, Hirata, Kenji, Watanabe, Shiro, Shiga, Tohru, Katoh, Chietsugu, Tamaki, Nagara
Format: Article
Language:English
Subjects:
18F-Fluorodeoxyglucose
Aged
AORTA
Aorta, Thoracic - diagnostic imaging
BLOOD
Blood Volume
Cardiology
CARDIOVASCULAR DISEASES
DIAGNOSIS
fasting
Female
FLUORODEOXYGLUCOSE
Fluorodeoxyglucose F18 - pharmacokinetics
GLUCOSE
Glucose - metabolism
Heart Diseases - diagnostic imaging
Heart Diseases - metabolism
Heart Diseases - physiopathology
Humans
Imaging
INFLAMMATION
Male
Medicine
Medicine & Public Health
METABOLISM
Metabolism: PET
Middle Aged
Myocardium - metabolism
NEOPLASMS
Nuclear Medicine
Original Article
PATIENTS
PET
physiological uptake
Physiology
POSITRON COMPUTED TOMOGRAPHY
Positron Emission Tomography Computed Tomography
Radiology
RADIOLOGY AND NUCLEAR MEDICINE
Radiopharmaceuticals - pharmacokinetics
Reproducibility of Results
Retrospective Studies
UPTAKE
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:FDG PET/CT plays a significant role in the diagnosis of inflammatory heart diseases and cardiac tumors. We attempted to determine the optimal FDG uptake threshold for volume-based analyses and to evaluate the relationship between the myocardial physiological uptake volume in FDG PET and several clinical factors. A total of 190 patients were retrospectively analyzed. The cardiac metabolic volume (CMV) was defined as a volume within the boundary determined by a threshold (SUVmean of blood pool × 1.5). The SUVmean of the blood pool measured in the descending aorta (DA) (r = 0.86, intraclass correlation coefficient [ICC] = 0.93, P < 0.0001) and that in the left ventricle (LV) cavity (r = 0.87, ICC = 0.90, P < 0.0001) showed high inter-operator reproducibility. However, the SUVmean in the LV cavity showed a significant correlation with the CMV (P = 0.0002, r = 0.26). The CMV in the patients who fasted < 18 hours were significantly higher (49.7 ± 73.2 vs. 18.0 ± 53.8 mL, P = 0.0013) compared to the patients with > 18-hour fasting. The multivariate analysis demonstrated that only the fasting period > 18 hours was independently associated with CMV = 0. Our findings revealed that the DA is suitable to decide the threshold for the volume-based analysis. The fasting time was significantly associated with the cardiac FDG uptake.
ISSN:1071-3581
1532-6551
1532-6551
DOI:10.1007/s12350-017-1122-6