Relationship of left ventricular global longitudinal strain with cardiac autonomic denervation as assessed by {sup 123}I-mIBG scintigraphy in patients with heart failure with reduced ejection fraction submitted to cardiac resynchronization therapy

Background: Heart failure (HF) is associated with cardiac autonomic denervation (AD), which can be non-invasively assessed by {sup 123}I-metaiodobenzylguanidine ({sup 123}I-mIBG) scintigraphy and has prognostic implications. We aimed to study the relationship between myocardial contractility assesse...

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Published in:Journal of nuclear cardiology 2019-06, Vol.26 (3)
Main Authors: Cruz, Madalena Coutinho, Abreu, Ana, Portugal, Guilherme, Santa-Clara, Helena, Cunha, Pedro S., Oliveira, Mario M., Santos, Vanessa, Oliveira, Luís, Rio, Pedro, Rodrigues, Inês, Morais, Luís A., Ferreira, Rui C., Carmo, Miguel M.
Format: Article
Language:English
Subjects:
AUC
CLINICAL TRIALS
HEART
HEART FAILURE
IODINE 123
MEDIASTINUM
MIBG
PATIENTS
RADIOLOGY AND NUCLEAR MEDICINE
SCINTISCANNING
WHO
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Summary:Background: Heart failure (HF) is associated with cardiac autonomic denervation (AD), which can be non-invasively assessed by {sup 123}I-metaiodobenzylguanidine ({sup 123}I-mIBG) scintigraphy and has prognostic implications. We aimed to study the relationship between myocardial contractility assessed by global longitudinal strain (GLS) and AD assessed by {sup 123}I-mIBG scintigraphy in advanced HF. Methods/Results: BETTER-HF is a prospective randomized clinical trial including HF patients (pts) submitted to cardiac resynchronization therapy (CRT) who are submitted to a clinical, echocardiographic, and scintigraphic assessment before and 6 months after CRT. 81 pts were included. An echocardiographic response (absolute increase in left ventricular ejection fraction ≥ 10%) was observed in 73.7% of pts. A higher baseline late heart-to-mediastinum ratio (HMR) was associated with a better echocardiographic response. There was a significant association between late HMR and GLS at baseline and 6 months. At baseline, GLS had an AUC of 0.715 for discrimination for a late HMR 
ISSN:1532-6551
1532-6551