Analyzing the post-contrast attenuation of the esophageal wall on routine contrast-enhanced MDCT examination can improve the diagnostic accuracy in response evaluation of the squamous cell esophageal carcinoma to neoadjuvant chemoradiotherapy in comparison with the esophageal wall thickness

Purpose To evaluate the accuracy of the multidetector computed tomography (MDCT) in the response evaluation of the esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT) by analyzing the thickness and post-contrast attenuation of the esophageal wall after the nCRT. Methods...

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Bibliographic Details
Published in:Abdominal imaging 2019-05, Vol.44 (5), p.1722-1733
Main Authors: Djuric-Stefanovic, Aleksandra, Jankovic, Aleksandra, Saponjski, Dusan, Micev, Marjan, Stojanovic-Rundic, Suzana, Cosic-Micev, Milena, Pesko, Predrag
Format: Article
Language:English
Subjects:
Accuracy
Attenuation
CARCINOMAS
Chemoradiotherapy
Chemotherapy
COMBINED THERAPY
Computed tomography
COMPUTERIZED TOMOGRAPHY
Diagnostic systems
Esophageal cancer
Esophageal carcinoma
ESOPHAGUS
Evaluation
Gastroenterology
Hepatology
Histopathology
Hollow Organ GI
Imaging
Medical diagnosis
Medicine
Medicine & Public Health
PATIENTS
Performance prediction
POLYMERASE CHAIN REACTION
Radiation therapy
Radiology
RADIOLOGY AND NUCLEAR MEDICINE
Regression analysis
Sensitivity
Squamous cell carcinoma
THICKNESS
Tumors
Wall thickness
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Summary:Purpose To evaluate the accuracy of the multidetector computed tomography (MDCT) in the response evaluation of the esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT) by analyzing the thickness and post-contrast attenuation of the esophageal wall after the nCRT. Methods Contrast-enhanced (CE)-MDCT examinations in portal venous phase of one hundred patients with locally advanced ESCC who received nCRT and underwent esophageal resection and histopathology assessment of tumor regression grade (TRG) were retrospectively analyzed by measuring the maximal thickness and mean density of the esophageal wall in the segment involved by tumor and visually searching for hyperdense foci within it. Diagnostic performance was evaluated using the ROC analysis. Results Average attenuation of the esophageal wall had stronger diagnostic performance for predicting pathologic complete regression (pCR) (AUC = 0.994; p 
ISSN:2366-004X
2366-0058
2366-0058
DOI:10.1007/s00261-019-01911-w