FOXK1 plays an oncogenic role in the development of esophageal cancer

Forkhead box k1 (FOXK1) is a member of the FOX class of transcription factors and it is dysregulated in many solid tumors including hepatocellular carcinoma, gastric cancer, colorectal cancer and prostate cancer. However, the expression status of FOXK1 and its clinical significance in esophageal can...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2017-12, Vol.494 (1-2), p.88-94
Main Authors: Chen, Di, Wang, Kai, Li, Xiaowei, Jiang, Mingzuo, Ni, Lu, Xu, Bing, Chu, Yi, Wang, Weijie, Wang, Hua, Kang, Huijie, Wu, Kaichun, Liang, Jie, Ren, Gui
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Adult
Aged
ANIMAL TISSUES
APOPTOSIS
BIOLOGICAL FUNCTIONS
Carcinogenesis - metabolism
Cell Differentiation
Cell Line, Tumor
Cell Movement
CELL PROLIFERATION
Esophageal cancer (EC)
Esophageal Neoplasms - etiology
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - pathology
ESOPHAGUS
Female
Forkhead box k1 (FOXK1)
Forkhead Transcription Factors - antagonists & inhibitors
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
HEPATOMAS
Humans
Immunohistochemistry
IN VITRO
INHIBITION
Kaplan-Meier Estimate
Male
Middle Aged
Migration
Oncogene Proteins - antagonists & inhibitors
Oncogene Proteins - genetics
Oncogene Proteins - metabolism
PATHOGENESIS
PATIENTS
Prognosis
Proliferation
PROSTATE
RNA, Small Interfering - genetics
TRANSCRIPTION
TRANSCRIPTION FACTORS
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Summary:Forkhead box k1 (FOXK1) is a member of the FOX class of transcription factors and it is dysregulated in many solid tumors including hepatocellular carcinoma, gastric cancer, colorectal cancer and prostate cancer. However, the expression status of FOXK1 and its clinical significance in esophageal cancer (EC) is still uncertain. Our study aimed at investigating the significance of FOXK1 expression in human EC and its biological function in the development of EC. We found that FOXK1 was overexpressed in EC tissues compared with corresponding non-tumor tissues using immunohistochemistry. And high FOXK1 expression was related to poor differentiation of EC. The Kaplan-Meier curve indicated that high FOXK1 expression may result in poor prognosis of EC patients. Furthermore, overexpression of FOXK1 in EC9706 cell inhibited cell apoptosis and promoted cell proliferation and migration, and suppression of FOXK1 in EC109 cell obtained reverse results. Our data suggest that FOXK1 plays an oncogenic role in EC pathogenesis and can serve as a therapeutic target for patients with EC. •It's the first time investigating the relationship between FOXK1 and esophageal cancer (EC).•FOXK1 could inhibit cell apoptosis and promote cell proliferation and migration of EC in vitro.•FOXK1 plays an oncogenic role in EC pathogenesis and can serve as a therapeutic target for patients with EC.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.10.080