MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence ha...

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Bibliographic Details
Published in:	Experimental cell research 2015-05, Vol.334 (1), p.173-182
Main Authors:	Lu, Ying-fei, Zhang, Li, Waye, Mary Miu Yee, Fu, Wei-ming, Zhang, Jin-fang
Format:	Article
Language:	eng
Subjects:	60 APPLIED LIFE SCIENCES APOPTOSIS CARCINOGENESIS Cell Transformation, Neoplastic - genetics Cellular biology COMPLEXES Gene expression HUMAN POPULATIONS Humans METASTASES Metastasis MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miR-218 Neoplasm Metastasis - genetics NEOPLASMS Neoplasms - genetics Neoplasms - pathology ONCOGENES Oncology REVIEWS RNA Target genes Tumorigenesis
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Summary:	MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. •miR-218 is frequently down regulated in multiple cancers.•miR-218 plays pivotal roles in carcinogenesis.•miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc.•miR-218 mediates tumorigenesis and metastasis via multiple pathways.
ISSN:	0014-4827 1090-2422