OTX1 promotes colorectal cancer progression through epithelial-mesenchymal transition

•OTX1 is overexpression in colorectal cancer tissues.•Overexpression of OTX1 promotes colorectal cancer cell proliferation and invasion in vitro and tumor growth in vivo.•Depletion of OTX1 inhibits colorectal cancer cell proliferation and invasion in vitro.•Overexpression of OTX1 is linked to the EM...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2014-01, Vol.444 (1), p.1-5
Main Authors: Yu, Kun, Cai, Xin-Yi, Li, Qiang, Yang, Zhi-Bin, Xiong, Wei, Shen, Tao, Wang, Wei-Ya, Li, Yun-Feng
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ANIMAL TISSUES
BRAIN
CARCINOGENESIS
Carcinogenesis - genetics
Carcinogenesis - metabolism
Cell Line, Tumor
Cell Movement
CELL PROLIFERATION
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Disease Progression
Epithelial-mesenchymal
Epithelial-Mesenchymal Transition - genetics
Epithelial-Mesenchymal Transition - physiology
HCT116 Cells
HUMAN POPULATIONS
Humans
IN VITRO
IN VIVO
Invasion
LARGE INTESTINE
NEOPLASMS
Oncogenes
Otx Transcription Factors - antagonists & inhibitors
Otx Transcription Factors - genetics
Otx Transcription Factors - metabolism
OTX1
PHENOTYPE
Proliferation
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Neoplasm - genetics
RNA, Neoplasm - metabolism
RNA, Small Interfering - genetics
TRANSCRIPTION FACTORS
Up-Regulation
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Summary:•OTX1 is overexpression in colorectal cancer tissues.•Overexpression of OTX1 promotes colorectal cancer cell proliferation and invasion in vitro and tumor growth in vivo.•Depletion of OTX1 inhibits colorectal cancer cell proliferation and invasion in vitro.•Overexpression of OTX1 is linked to the EMT-like phenotype. Orthodenticle homeobox 1 (OTX1), a transcription factor containing a bicoid-like homeodomain, plays a role in brain and sensory organ development. In this study, we report that OTX1 is overexpressed in human colorectal cancer (CRC) and OTX1 overexpression is associated with higher stage. Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro. Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2013.12.125