Temporal Nodal Regression and Regional Control After Primary Radiation Therapy for N2-N3 Head-and-Neck Cancer Stratified by HPV Status

Purpose To compare the temporal lymph node (LN) regression and regional control (RC) after primary chemoradiation therapy/radiation therapy in human papillomavirus-related [HPV(+)] versus human papillomavirus-unrelated [HPV(−)] head-and-neck cancer (HNC). Methods and Materials All cases of N2-N3 HNC...

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Published in:International journal of radiation oncology, biology, physics biology, physics, 2013-12, Vol.87 (5), p.1078-1085
Main Authors: Huang, Shao Hui, MD, MRT(T), O'Sullivan, Brian, MD, Xu, Wei, PhD, Zhao, Helen, MSc, Chen, Duo-duo, BSc, Ringash, Jolie, MD, Hope, Andrew, MD, Razak, Albiruni, MD, Gilbert, Ralph, MD, Irish, Jonathan, MD, Kim, John, MD, Dawson, Laura A., MD, Bayley, Andrew, MD, Cho, B.C. John, MD, Goldstein, David, MD, Gullane, Patrick, MD, Yu, Eugene, MD, Perez-Ordonez, Bayardo, MD, Weinreb, Ilan, MD, Waldron, John, MD
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Language:eng
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Summary:Purpose To compare the temporal lymph node (LN) regression and regional control (RC) after primary chemoradiation therapy/radiation therapy in human papillomavirus-related [HPV(+)] versus human papillomavirus-unrelated [HPV(−)] head-and-neck cancer (HNC). Methods and Materials All cases of N2-N3 HNC treated with radiation therapy/chemoradiation therapy between 2003 and 2009 were reviewed. Human papillomavirus status was ascertained by p16 staining on all available oropharyngeal cancers. Larynx/hypopharynx cancers were considered HPV(−). Initial radiologic complete nodal response (CR) (≤1.0 cm 8-12 weeks after treatment), ultimate LN resolution, and RC were compared between HPV(+) and HPV(−) HNC. Multivariate analysis identified outcome predictors. Results A total of 257 HPV(+) and 236 HPV(−) HNCs were identified. The initial LN size was larger (mean, 2.9 cm vs 2.5 cm; P
ISSN:0360-3016
1879-355X