Generation of drugs coated iron nanoparticles through high energy ball milling

The iron nanoparticles coated with oleic acid and drugs such as folic acid/Amoxicillin were synthesized by high energy ball milling and characterized by X-ray diffraction, Transmission electron microscope, zeta potential, dynamic light scattering, Fourier Transform Infra red (FT-IR) measurements, an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied physics 2014-03, Vol.115 (12)
Main Authors: Radhika Devi, A., Chelvane, J. A., Prabhakar, P. K., Padma Priya, P. V., Doble, Mukesh, Murty, B. S.
Format: Article
Language:English
Subjects:
Acids
ADSORPTION
Amoxicillin
Applied physics
Ball milling
Biocompatibility
Coated particles
Coating
COMPARATIVE EVALUATIONS
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
Drugs
Energy transmission
FOLIC ACID
FOURIER TRANSFORMATION
Fourier transforms
Gravimetric analysis
INFRARED SPECTRA
Infrared spectroscopy
IRON
Light diffraction
LIGHT SCATTERING
Magnetic measurement
Magnetic saturation
MAGNETIZATION
MILLING
Nanoparticles
NANOSCIENCE AND NANOTECHNOLOGY
NANOSTRUCTURES
OLEIC ACID
PARTICLES
Photon correlation spectroscopy
THERMAL GRAVIMETRIC ANALYSIS
Toxicity
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION
Zeta potential
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The iron nanoparticles coated with oleic acid and drugs such as folic acid/Amoxicillin were synthesized by high energy ball milling and characterized by X-ray diffraction, Transmission electron microscope, zeta potential, dynamic light scattering, Fourier Transform Infra red (FT-IR) measurements, and thermo gravimetric analysis (TGA). FT-IR and TGA measurements show good adsorption of drugs on oleic acid coated nanoparticles. Magnetic measurements indicate that saturation magnetization is larger for amoxicillin coated particles compared to folic acid coated particles. The biocompatibility of the magnetic nanoparticles prepared was evaluated by in vitro cytotoxicity assay using L929 cells as model cells.
ISSN:0021-8979
1089-7550
DOI:10.1063/1.4868681