Routine production of copper-64 using 11.7MeV protons

Reliable production of copper-64 ({sup 64}Cu) was achieved by irradiating enriched nickel-64 ({sup 64}Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 {+-} 3.0 mg) was electroplated onto an Au disc (125{mu}m Multiplication-Sign 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours...

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Main Authors: Jeffery, C. M., Smith, S. V., Asad, A. H., Chan, S., Price, R. I., Centre for Forensic Science, University of Western Australia, Nedlands, Western Australia, 6009, ARC Centre of Excellence in Antimatter-Matter Studies, Australian National University, Canberra, ACT 0200, Medical Technology and Physics, Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009
Format: Conference Proceeding
Language:English
Subjects:
07 ISOTOPES AND RADIATION SOURCES
ALCOHOLS
COBALT 61
COPPER 64
CYCLOTRONS
ELECTROPLATING
GOLD IONS
HYDROCHLORIC ACID
ICP MASS SPECTROSCOPY
IMPURITIES
ION EXCHANGE
IRRADIATION
ISOTOPE PRODUCTION
ISOTOPE SEPARATION
MEV RANGE
NICKEL 64
PROTON REACTIONS
RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY
RADIOCHEMISTRY
TITRATION
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Summary:Reliable production of copper-64 ({sup 64}Cu) was achieved by irradiating enriched nickel-64 ({sup 64}Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 {+-} 3.0 mg) was electroplated onto an Au disc (125{mu}m Multiplication-Sign 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40{mu}A. Copper isotopes ({sup 60,61,62,64}Cu) were separated from target nickel and cobalt isotopes ({sup 55,57,61}Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The {sup 64}Ni target material was recovered and reused. The {sup 64}Cu production rate was 1.46{+-}0.3MBq/{mu}A.hr/mg{sup 64}Ni(n = 10) (with a maximum of 2.6GBq of {sup 64}Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the {sup 64}Cu was 98.7 {+-} 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of {sup 64}Cu was determined by ICP-MS and by titration with Diamsar to be 28.9{+-}13.0GBq/{mu}mol[0.70{+-}0.35Ci/{mu}mol]/({mu}A.hr/mg{sup 64}Ni)(n = 10) and 13.1{+-}12.0GBq/{mu}mol[0.35{+-}0.32Ci/{mu}mol]/({mu}A.hr/mg{sup 64}Ni)(n 9), respectively; which are in agreement, however, further work is required.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4773946