Blood oxygenation monitoring by diffuse optical tomography

Diffuse optical tomography (DOT) makes it possible to reconstruct, in two or three dimensions, the internal structure of the biological tissues based on the distribution of the absorption coefficient and the reduced scattering coefficient, using optical measurements at multiple source - detector pos...

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Bibliographic Details
Published in:Quantum electronics (Woodbury, N.Y.) N.Y.), 2011-01, Vol.40 (12), p.1062-1066
Main Authors: Patachia, M, D.C.A., Dutu, D.C., Dumitras
Format: Article
Language:English
Subjects:
ABSORPTION
ABSORPTION SPECTROSCOPY
ACCURACY
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
DIAGNOSTIC TECHNIQUES
DISEASES
GLOBINS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFRARED SPECTRA
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
LASERS
MATERIALS
MONITORING
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
SCATTERING
SORPTION
SPECTRA
SPECTROSCOPY
TOMOGRAPHY
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Description
Summary:Diffuse optical tomography (DOT) makes it possible to reconstruct, in two or three dimensions, the internal structure of the biological tissues based on the distribution of the absorption coefficient and the reduced scattering coefficient, using optical measurements at multiple source - detector positions on the tissue surface. The measurement of the light intensity transmitted through the tissue can be also used to compute the haemoglobin and oxyhaemoglobin concentrations, measuring the selective absorption of the main blood chromophores by near infrared spectroscopy (NIRS). The spectral selectivity of the system and the evaluation of the blood volume and blood oxygenation (BV and OXY distributions), together with the reconstruction of the inner structure of the tissue, can improve the accuracy of early cancer diagnosis, based on the tissue angiogenesis characterisation. (application of lasers and laser-optical methods in life sciences)
ISSN:1063-7818
1468-4799
DOI:10.1070/QE2010v040n12ABEH014505