Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death

The efficacy of methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often limited by severe side effects and toxic sequelae. Regarding the mechanisms of these side effects, several hypotheses have been put forward, among which oxidative stress is noticeable. The present study was...

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Bibliographic Details
Published in:Toxicology and applied pharmacology 2005-11, Vol.209 (1), p.39-50
Main Authors: Çetiner, Mustafa, Şener, Göksel, Şehirli, A. Özer, Ekşioğlu-Demiralp, Emel, Ercan, Feriha, Şirvancı, Serap, Gedik, Nursal, Akpulat, Sertaç, Tecimer, Tülay, Yeğen, Berrak Ç.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Alanine Transaminase - blood
Animals
Annexin A5 - metabolism
Antimetabolites, Antineoplastic - toxicity
APOPTOSIS
Apoptosis - drug effects
Aspartate Aminotransferases - blood
Biological and medical sciences
BONE MARROW
Cell Death - drug effects
COLLAGEN
Collagen - metabolism
EPITHELIUM
Female
Free Radical Scavengers - pharmacology
GLUTATHIONE
Glutathione - metabolism
Hematocrit
Hemoglobins - metabolism
INJURIES
KIDNEYS
Leukocytes - drug effects
LIVER
Male
Malondialdehyde - metabolism
Medical sciences
METHOTREXATE
Methotrexate - antagonists & inhibitors
Methotrexate - toxicity
MUCOUS MEMBRANES
Myeloperoxidase
NEUTROPHILS
Neutrophils - drug effects
Neutrophils - immunology
Oxidative injury
Peroxidase - metabolism
RATS
Rats, Wistar
SIDE EFFECTS
SMALL INTESTINE
TAURINE
Taurine - pharmacology
TOXICITY
Toxicology
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Summary:The efficacy of methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often limited by severe side effects and toxic sequelae. Regarding the mechanisms of these side effects, several hypotheses have been put forward, among which oxidative stress is noticeable. The present study was undertaken to determine whether taurine, a potent free radical scavenger, could ameliorate MTX-induced oxidative injury and modulate immune response. Following a single dose of methotrexate (20 mg/kg), either saline or taurine (50 mg/kg) was administered for 5 days. After decapitation of the rats, trunk blood was obtained and the ileum, liver, and kidney were removed to measure malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, and collagen content, as well as histological examination. Our results showed that MTX administration increased the MDA, MPO activity, and collagen contents and decreased GSH levels in all tissues ( P 
ISSN:0041-008X
1096-0333
DOI:10.1016/j.taap.2005.03.009