Magnesium and fluoride doped hydroxyapatite coatings grown by pulsed laser deposition for promoting titanium implant cytocompatibility

Mg and F were added into hydroxyapatite structure in order to develop continuous bioactive coatings by pulsed laser deposition. After soaking for 7 days, the coatings exhibited different microstructure: rice-like nano-porous structure (F-HA coating), 3D porous network structure (Mg-HA coating) and a...

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Bibliographic Details
Published in:Applied surface science 2020-06, Vol.515 (C), p.146069, Article 146069
Main Authors: Cao, Jinxing, Lian, Ruizhe, Jiang, Xiaohong
Format: Article
Language:English
Subjects:
Cytocompatibility
Fluoride
Hydroxyapatite
Magnesium
Porous structure
Pulsed laser deposition
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Summary:Mg and F were added into hydroxyapatite structure in order to develop continuous bioactive coatings by pulsed laser deposition. After soaking for 7 days, the coatings exhibited different microstructure: rice-like nano-porous structure (F-HA coating), 3D porous network structure (Mg-HA coating) and an ordered linear structure similar to cancellous bone (Mg-F-HA coating). All the coatings show rapid biomineralization and cell proliferation, especially Mg-F-HA coating. Furthermore, the cell viability and morphology of Mg-F-HA coating was comparable to that of the control sample after culturing for 3 weeks. [Display omitted] •F doped HA coating enhance the interfacial bonding and the substrate bioactivity.•Mg doped HA can regulate the coating degradation rate and induce cell proliferation.•Mg-F-HA coating exhibit a linear structure similar to cancellous bone after soaking.•Mg-F-HA coating show sustained viability in biomineralization and cell proliferation. Magnesium (Mg) and fluoride (F) ions hold promising perspective for bone tissue regeneration by stimulating osteoblast cells proliferation and differentiation. Inspired by bone structure, Mg/F doped hydroxyapatite (HA) coatings with rapid surface apatite deposition ability and robust cytocompatibility will be an ideal bioactive coating for the surface functionalization of titanium implants. In this study, F doped HA (F-HA) coating, Mg doped HA (Mg-HA) coating and two superimposed double (Mg-F-HA) coatings were fabricated on titanium substrate by using pulsed laser deposition. In vitro bioactivity studies showed that three coatings exhibited different microstructure after soaking for 7 days: rice-like nano-porous structure (F-HA coating), 3D porous network structure (Mg-HA coating) and an ordered linear structure similar to cancellous bone (Mg-F-HA coating). For Mg-F-HA coating, it can better promote the transformation from apatite-like to HA phase due to the synergistic effect of Mg and F. Cell viability studies indicate that Mg/F doped HA coating can hold a good biocompatibility without cytotoxicity and improve the interfacial bioactivity of titanium substrate, specifically, both on regulation of biodegradation rate and good cellular proliferation. In summary, Mg/F doped HA structure yields a sustained bioactive coating for surface modification of titanium implant for rapid cell proliferation.
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2020.146069