Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrod...

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Bibliographic Details
Published in:ACS sensors 2016-07, Vol.1 (7), p.866-874
Main Authors: Gao, Wei, Nyein, Hnin Y. Y, Shahpar, Ziba, Fahad, Hossain M, Chen, Kevin, Emaminejad, Sam, Gao, Yuji, Tai, Li-Chia, Ota, Hiroki, Wu, Eric, Bullock, James, Zeng, Yuping, Lien, Der-Hsien, Javey, Ali
Format: Article
Language:English
Subjects:
flexible electronics
heavy metals monitoring
multiplexed sensing
OTHER INSTRUMENTATION
sweat
temperature compensation
wearable biosensors
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Summary:A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual’s health state such as heavy metal exposure and aid the related clinical investigations.
ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.6b00287