Large Scale Nanoparticle Screening for Small Molecule Analysis in Laser Desorption Ionization Mass Spectrometry

Nanoparticles (NPs) have been suggested as efficient matrixes for small molecule profiling and imaging by laser-desorption ionization mass spectrometry (LDI-MS), but so far there has been no systematic study comparing different NPs in the analysis of various classes of small molecules. Here, we pres...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2016-09, Vol.88 (18), p.8926-8930
Main Authors: Yagnik, Gargey B, Hansen, Rebecca L, Korte, Andrew R, Reichert, Malinda D, Vela, Javier, Lee, Young Jin
Format: Article
Language:English
Subjects:
Desorption
Efficiency
Guidelines
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Ionization
Mass spectrometry
MATERIALS SCIENCE
Metabolites
Metal oxides
Molecules
Nanoparticles
Screening
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Summary:Nanoparticles (NPs) have been suggested as efficient matrixes for small molecule profiling and imaging by laser-desorption ionization mass spectrometry (LDI-MS), but so far there has been no systematic study comparing different NPs in the analysis of various classes of small molecules. Here, we present a large scale screening of 13 NPs for the analysis of two dozen small metabolite molecules. Many NPs showed much higher LDI efficiency than organic matrixes in positive mode and some NPs showed comparable efficiencies for selected analytes in negative mode. Our results suggest that a thermally driven desorption process is a key factor for metal oxide NPs, but chemical interactions are also very important, especially for other NPs. The screening results provide a useful guideline for the selection of NPs in the LDI-MS analysis of small molecules.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.6b02732