Configuration of membrane-bound proteins by x-ray reflectivity

In this presentation we review our recent work using x-ray reflectivity to determine the configuration of membrane-bound proteins. The reflectivity data is analyzed in terms of the known crystallographic structure of proteins and a slab model representing the lipid layer to yield an electron density...

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Bibliographic Details
Published in:Journal of applied physics 2011-11, Vol.110 (10), p.102215-102215-4
Main Authors: Chen, Chiu-Hao, Málková, Šárka, Cho, Wonhwa, Schlossman, Mark L.
Format: Article
Language:English
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Summary:In this presentation we review our recent work using x-ray reflectivity to determine the configuration of membrane-bound proteins. The reflectivity data is analyzed in terms of the known crystallographic structure of proteins and a slab model representing the lipid layer to yield an electron density profile of the lipid/protein system. Our recent modified analysis methodology for the lipid/protein system is concisely described in this report. In addition, some results of the configuration of the membrane-bound proteins cPLA 2 α-C2, p40 phox -PX, and PKCα-C2 are highlighted.
ISSN:0021-8979
1089-7550
DOI:10.1063/1.3661985