Glycolytic Difference between Foetal and Non-foetal Human Fibroblast Lines

DURING multiple passages, fibroblast cell lines retain the chromosome number and genetic defects of the original donor1,2. Here we show, by comparing the modes of glycolysis in foetal and non-foetal skin cultures, that-fibroblasts retain the expression of their original developmental state.

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Bibliographic Details
Published in:Nature (London) 1971-02, Vol.229 (7), p.214-215
Main Authors: CONDON, M. A. A, OSKI, F. A, DIMAURO, S, MELLMAN, W. J
Format: Article
Language:English
Subjects:
Carbon Dioxide - metabolism
Carbon Isotopes
Cell Line - metabolism
DNA - biosynthesis
Female
Fetus - metabolism
Fibroblasts - metabolism
Glycolysis
Humans
In Vitro Techniques
Lactates - biosynthesis
Pregnancy
Skin - cytology
Thymidine - metabolism
Tritium
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Description
Summary:DURING multiple passages, fibroblast cell lines retain the chromosome number and genetic defects of the original donor1,2. Here we show, by comparing the modes of glycolysis in foetal and non-foetal skin cultures, that-fibroblasts retain the expression of their original developmental state.
ISSN:0028-0836
0090-0028
1476-4687
2058-1092
DOI:10.1038/newbio229214a0