Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare

The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their anti-inflammatory activity are reported for the first time. We evaluated the inhibitory effects...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of ethnopharmacology 2002-03, Vol.79 (3), p.389-392
Main Authors:	SAHPAZ, Sevser, GARBACKI, Nancy, TITS, Monique, BAILLEUL, Francois
Format:	Article
Language:	eng
Subjects:	anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Biologie végétale (sciences végétales, sylviculture, mycologie...) Caffeic Acids - chemistry Caffeic Acids - pharmacology Chemistry Chimie cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - isolation & purification Cyclooxygenase Inhibitors - pharmacology Esters General pharmacology Glycosides - chemistry Glycosides - pharmacology Human health sciences Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Life sciences Malates - chemistry Malates - pharmacology Marrubium - chemistry Marrubium vulgare Medical sciences Pharmacie, pharmacologie & toxicologie Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Pharmacy, pharmacology & toxicology phenylpropanoid esters Physical, chemical, mathematical & earth Sciences Physique, chimie, mathématiques & sciences de la terre Phytobiology (plant sciences, forestry, mycology...) Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Structures - chemistry Propanols - chemistry Propanols - isolation & purification Propanols - pharmacology Prostaglandin-Endoperoxide Synthases - metabolism Sciences de la santé humaine Sciences du vivant
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their anti-inflammatory activity are reported for the first time. We evaluated the inhibitory effects of these five compounds on cyclooxygenase (Cox) catalysed prostaglandin biosynthesis activity. Only the glycosidic phenylpropanoid esters showed an inhibitory activity towards the Cox-2 enzyme and three of them: acteoside 2, forsythoside B 3, arenarioside 4, exhibited higher inhibitory potencies on Cox-2 than on Cox-1. These results are of interest, as Cox-2 is mainly associated with inflammation and the Cox-1 inhibition with adverse side effects often observed with non-steroidal anti-inflammatory drugs. The occurrence of these phenylpropanoid esters could also explain some other pharmacological properties of M. vulgare.
ISSN:	0378-8741 1872-7573 1872-7573