Childhood ALL and second neoplasms

Second malignancies are a significant concern for survivors of childhood acute lymphoblastic leukemia (ALL), in particular patients who have been treated with cranial irradiation. Brain tumors, most commonly meningiomas, are among the most common second neoplasms discovered in these patients. Breast...

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Bibliographic Details
Published in:Cancer biology & therapy 2007-10, Vol.6 (10), p.1525-1531
Main Authors: Maniar, Tapan N., Braunstein, Inbal, Keefe, Stephen, Hussen, Sofia, Abrams, Tara, De Michele, Angela, El-Deiry, Wafik S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Binding
Biology
Bioscience
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Calcium
Cancer
Cell
Child
Child, Preschool
Cycle
Female
Humans
Landes
Male
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - epidemiology
Meningeal Neoplasms - genetics
Meningioma - diagnosis
Meningioma - epidemiology
Meningioma - genetics
Meningioma - pathology
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - genetics
Organogenesis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Proteins
Risk
Citations: Items that cite this one
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Description
Summary:Second malignancies are a significant concern for survivors of childhood acute lymphoblastic leukemia (ALL), in particular patients who have been treated with cranial irradiation. Brain tumors, most commonly meningiomas, are among the most common second neoplasms discovered in these patients. Breast cancer can occur in association with meningioma, but is not thought to be a consequence of treatment for childhood ALL. We describe the molecular genetics and therapy of childhood ALL, the molecular genetics of meningioma, as well as the possible association between meningioma and breast cancer.
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.6.10.4928