Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production

Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this p...

Full description

Saved in:
Bibliographic Details
Published in:Journal of microbiology and biotechnology 2021-11, Vol.31 (11), p.1465-1480
Main Authors: Ahmed, Aqsa, Ahmad, Abdullah, Li, Renhan, AL-Ansi, Waleed, Fatima, Momal, Mushtaq, Bilal Sajid, Basharat, Samra, Li, Ye, Bai, Zhonghu
Format: Article
Language:Korean
Subjects:
biological applications
heterologous production
industrial applications
metabolic engineering
synthetic biology
Violacein
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this pigment, which include (1) fundamental studies of its biosynthetic pathway, (2) production of violacein by native producers, apart from C. violaceum, (3) metabolic engineering for improved production in heterologous hosts such as Escherichia coli, Citrobacter freundii, Corynebacterium glutamicum, and Yarrowia lipolytica, (4) biological/pharmaceutical and industrial properties, (5) and applications in synthetic biology. Due to the intrinsic properties of violacein and the intermediates during its biosynthesis, the prospective research has huge potential to move this pigment into real clinical and industrial applications.
ISSN:1017-7825
1738-8872