Association of UDP-galactose-4-epimerase with milk protein concentration in the Chinese Holstein population

Objective: An initial RNA-Sequencing study revealed that UDP-galactose-4-epimerase (GALE) was one of the most promising candidates for milk protein concentration in Chinese Holstein cattle. This enzyme catalyzes the interconversion of UDP-galactose and UDP-glucose, an important step in galactose cat...

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Published in:Asian-australasian journal of animal sciences 2020, Vol.33 (11), p.1725-1731
Main Authors: Li, Cong, Cai, Wentao, Liu, Shuli, Zhou, Chenghao, Cao, Mingyue, Yin, Hongwei, Sun, Dongxiao, Zhang, Shengli, Loor, Juan J
Format: Article
Language:Korean
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Summary:Objective: An initial RNA-Sequencing study revealed that UDP-galactose-4-epimerase (GALE) was one of the most promising candidates for milk protein concentration in Chinese Holstein cattle. This enzyme catalyzes the interconversion of UDP-galactose and UDP-glucose, an important step in galactose catabolism. To further validate the genetic effect of GALE on milk protein traits, genetic variations were identified, and genotypes-phenotypes associations were performed. Methods: The entire coding region and the 5'-regulatory region (5'-UTR) of GALE were re-sequenced using pooled DNA of 17 unrelated sires. Association studies for five milk production traits were performed using a mixed linear animal model with a population encompassing 1,027 Chinese Holstein cows. Results: A total of three variants in GALE were identified, including two novel variants (g.2114 A>G and g.2037 G>A) in the 5'-UTR and one previously reported variant (g.3836 G>C) in an intron. All three single nucleotide polymorphisms (SNPs) were associated with milk yield (p
ISSN:1011-2367
1976-5517