Validation of Serum Aminotransferases Levels to Define Severe Dengue Fever in Children

Purpose: We aimed to study the pattern of liver-injury in children with dengue fever (DF) and validate serum aminotransferase ${\geq}1,000IU/L$ as a marker of severe DF. Methods: Children admitted with DF were included. DF was defined by presence of clinical criteria and positive serological or anti...

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Published in:Pediatric gastroenterology, hepatology & nutrition hepatology & nutrition, 2018, Vol.21 (4), p.289-296
Main Authors: Srivastava, Geetika, Chhavi, Nanda, Goel, Amit
Format: Article
Language:Korean
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Summary:Purpose: We aimed to study the pattern of liver-injury in children with dengue fever (DF) and validate serum aminotransferase ${\geq}1,000IU/L$ as a marker of severe DF. Methods: Children admitted with DF were included. DF was defined by presence of clinical criteria and positive serological or antigen tests in absence of other etiology. DF severity was graded as dengue without or with warning signs and severe dengue. Liver-injury was defined as alanine aminotransferase (ALT) more than twice the upper limit of normal (boys, 30 IU/L; girls, 21 IU/L). Results: Of 372 children with DF, 144 (38.7%) had liver-injury. Risk of liver-injury and aminotransferase levels increased with DF severity (p
ISSN:2234-8646
2234-8840