Chemopreventive Activity of Turmeric Essential Oil and Possible Mechanisms of Action

This study aimed to evaluate the antimutagenic and anticarcinogenic activity of turmeric essential oil as well as to establish biochemical mechanisms of action. Antimutagenicity testing was accomplished using strains and known mutagens with and without microsomal activation. Anticarcinogenic activit...

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Bibliographic Details
Published in:Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 (16), p.6575-6580
Main Authors: Liju, Vijayasteltar Belsamma, Jeena, Kottarapat, Kuttan, Ramadasan
Format: Article
Language:Korean
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Summary:This study aimed to evaluate the antimutagenic and anticarcinogenic activity of turmeric essential oil as well as to establish biochemical mechanisms of action. Antimutagenicity testing was accomplished using strains and known mutagens with and without microsomal activation. Anticarcinogenic activity was assessed by topical application of 7, 12 - dimethylbenz[a]anthracene (DMBA) as initiator and 1% croton oil as promoter for the induction of skin papillomas in mice. Inhibition of p450 enzymes by TEO was studied using various resorufins and aminopyrene as substrate. Turmeric essential oil (TEO) showed significant antimutagenic activity (p
ISSN:1513-7368
2476-762X