Case Report : Acute oxalate nephropathy caused by ethylene glycol poisoning

Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life...

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Bibliographic Details
Published in:Kidney research and clinical practice 2012-09, Vol.31 (3), p.249
Main Authors: Jung Woong Seo, Jong Ho Lee, In Sung Son, Yong Jin Kim, Do Young Kim, Yong Hwang, Hyun Ah Chung, Hong Seok Choi, So Dug Lim
Format: Article
Language:Korean
Subjects:
Acute kidney injury
Calcium oxalate
Ethylene glycol
Metabolic acidosis
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Summary:Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life-threatening metabolic acidosis, central nervous system depression, and kidney injury. Oxalic acid is the end product of EG, which can precipitate to crystals of calcium oxalate monohydrate in the tubular lumen and has been linked to acute kidney injury. We report a case of EG-induced oxalate nephropathy, with the diagnosis confirmed by kidney biopsy, which showed acute tubular injury of the kidneys with extensive intracellular and intraluminal calcium oxalate monohydrate crystal depositions.
ISSN:2211-9132