Serum Magnesium Level and Clinical Deterioration in Alzheimer’s Disease

Background: Recent studies suggest that magnesium, which specially affects the N-methyl-D-aspartate receptor response to excitatory amino acids, may be a supportive therapeutic agent in Alzheimer’s disease. Objective: To investigate the relationship between magnesium levels and the cognitive test re...

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Bibliographic Details
Published in:	Gerontology (Basel) 2007-01, Vol.53 (6), p.419-422
Main Authors:	Cilliler, Asli Ece, Ozturk, Serefnur, Ozbakir, Senay
Format:	Article
Language:	eng
Subjects:	Alzheimer Disease - blood Alzheimer Disease - classification Alzheimers disease Biological and medical sciences Case-Control Studies Clinical Section Cognition & reasoning Development. Metamorphosis. Moult. Ageing Disease Progression Female Fundamental and applied biological sciences. Psychology Gerontology Humans Magnesium Magnesium - blood Male Older people Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:	Background: Recent studies suggest that magnesium, which specially affects the N-methyl-D-aspartate receptor response to excitatory amino acids, may be a supportive therapeutic agent in Alzheimer’s disease. Objective: To investigate the relationship between magnesium levels and the cognitive test results and clinical stages of the patients. Methods: Thirty-seven patients (20 women, 17 men) and 34 controls were included in the study. The patients were staged according to Global Deterioration Scale (GDS) and Clinical Dementia Rating (CDR). Results: There was a significant difference for Mg levels according to GDS (p = 0.030). Similarly, Mg levels were different between patients with low and high CDR stages (p = 0.003). Mg levels were lower in the group whose MMSE scores were
ISSN:	0304-324X 1423-0003