Synchronous B-Cell Acute Lymphoblastic Leukemia and Serous Ovarian Carcinoma: A Case Report

Abstract Adult patients with B-cell acute lymphoblastic leukemia (ALL) have higher rates of antecedent and subsequent malignancies. However, synchronous identification of ALL and ovarian cancer is exceedingly rare. We report the unique case of a 65-year-old woman with synchronous B-cell ALL and low-...

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Bibliographic Details
Published in:Case reports in oncology 2021-11, Vol.14 (3), p.1621-1626
Main Authors: Superdock, Michael, Komisarof, Justin, Katerji, Hani, Huselton, Eric
Format: Article
Language:English
Subjects:
Abdomen
Adults
Biopsy
Bone marrow
Cancer therapies
Case Report
Case reports
Chemotherapy
Clinical trials
Flow cytometry
Intestinal obstruction
Laparotomy
Leukemia
malignancy
Medical prognosis
Monoclonal antibodies
Nervous system
Ovarian cancer
ovarian carcinoma
Patients
Pelvis
Remission (Medicine)
Targeted cancer therapy
Thrombocytopenia
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Summary:Abstract Adult patients with B-cell acute lymphoblastic leukemia (ALL) have higher rates of antecedent and subsequent malignancies. However, synchronous identification of ALL and ovarian cancer is exceedingly rare. We report the unique case of a 65-year-old woman with synchronous B-cell ALL and low-grade serous ovarian carcinoma diagnosed after surgical intervention for a small bowel obstruction. Treatment with inotuzumab ozogamicin followed by adnexal mass resection and postoperative letrozole was successful in achieving complete remission for both her leukemia and ovarian cancer.
ISSN:1662-6575
1662-6575
DOI:10.1159/000519743