Possible Neurophysiological Markers of Genetic Predisposition to Alzheimer’s Disease

Visual-evoked potentials (VEP) to a flash were studied in the first-order relatives of patients with Alzheimer’s disease (AD) (mean age 38.2 ± 2.6 years) in comparison with the patients (mean age 61.9 ± 1.4 years) and age-matched normal controls. It was found that in the relatives of AD patients the...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 1998-09, Vol.9 (5), p.267-273
Main Authors: Ponomareva, N.V., Fokin, V.F., Selesneva, N.D., Voskresenskaia, N.I.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aging - physiology
Alzheimer Disease - genetics
Alzheimer Disease - physiopathology
Alzheimer's disease
Evoked Potentials, Visual - physiology
Family Health
Humans
Middle Aged
Original Research Article
Predictive Value of Tests
Reaction Time - physiology
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Summary:Visual-evoked potentials (VEP) to a flash were studied in the first-order relatives of patients with Alzheimer’s disease (AD) (mean age 38.2 ± 2.6 years) in comparison with the patients (mean age 61.9 ± 1.4 years) and age-matched normal controls. It was found that in the relatives of AD patients the latencies of N2, P3, N3 components were delayed compared with the age-matched normal controls. The delay in the latencies of the patients and their relatives concerned the same components but was smaller in the relatives of AD patients. The amplitude of the P2, N2 components was increased in the latter. The neurophysiological alteration in AD patients’ relatives may be considered as signs of a latent neurodegeneration in limbico-reticulo-cortical pathways, which may be connected to the pathological hyperactivity of limbico-reticulo-cortical structures.
ISSN:1420-8008
1421-9824
DOI:10.1159/000017071