Non–invasive measurements of breast tissue optical properties using frequency–domain photon migration

A multiwavelength, high bandwidth (1 GHz) frequency-domain photon migration (FDPM) instrument has been developed for quantitative, non-invasive measurements of tissue optical and physiological properties. The instrument produces 300 kHz to 1 GHz photon density waves (PDWs) in optically turbid media...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 1997-06, Vol.352 (1354), p.661-668
Main Authors: Tromberg, Bruce J., Coquoz, Olivier, Fishkin, Joshua B., Pham, Tuan, Anderson, Eric R., Butler, John, Cahn, Mitchell, Gross, Jeffrey D., Venugopalan, Vasan, Pham, David
Format: Article
Language:English
Subjects:
Adipose tissues
Adult
Amplitude
Biopsy, Needle
Body tissues
Breast - cytology
Breast - pathology
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Breasts
Female
Fibrocystic Breast Disease - diagnosis
Fibrocystic Breast Disease - pathology
Hemoglobins - analysis
Humans
Lesions
Middle Aged
Neoplasia
Optical properties
Oxyhemoglobins - analysis
Photon density
Photons
Postmenopause
Premenopause
Reference Values
Reproducibility of Results
Spectrophotometry, Infrared - instrumentation
Spectrophotometry, Infrared - methods
Wavelengths
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Description
Summary:A multiwavelength, high bandwidth (1 GHz) frequency-domain photon migration (FDPM) instrument has been developed for quantitative, non-invasive measurements of tissue optical and physiological properties. The instrument produces 300 kHz to 1 GHz photon density waves (PDWs) in optically turbid media using a network analyser, an avalanche photodiode detector and four amplitude-modulated diode lasers (674 nm, 811 nm, 849 nm and 956 nm). The frequency-dependence of PDW phase and amplitude is measured and compared to analytically derived model functions in order to calculate absorption, μa, and reduced scattering, μ′s, parameters. The wavelength-dependence of absorption is used to determine tissue haemoglobin concentration (total, oxy- and deoxy- forms), oxygen saturation and water concentration. We present preliminary results of non-invasive FDPM measurements obtained from normal and tumour-containing human breast tissue. Our data clearly demonstrate that physiological changes caused by the presence of small (about 1 cm diameter) palpable lesions can be detected using a handheld FDPM probe.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.1997.0047