Noncovalent Functionalization of Carbon Nanotubes for Highly Specific Electronic Biosensors

Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific el...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-04, Vol.100 (9), p.4984-4989
Main Authors: Chen, Robert J., Bangsaruntip, Sarunya, Drouvalakis, Katerina A., Nadine Wong Shi Kam, Shim, Moonsub, Li, Yiming, Kim, Woong, Utz, Paul J., Dai, Hongjie
Format: Article
Language:English
Subjects:
Adsorption
Biosensing Techniques
Biosensors
Carbon
Carbon nanotubes
Chemical suspensions
Electrodes
Material films
Microscopy, Atomic Force
Molecules
Nanotechnology
Nanotubes
Narrative devices
Physical Sciences
Semiconductors
Vapor deposition
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Summary:Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0837064100