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Postmortem Memantine Concentrations
Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to a...
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Published in: | Journal of Analytical Toxicology 2007, Vol.31 (4), p.233-236 |
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Main Authors: | , , , |
Format: | Report |
Language: | English |
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container_end_page | 236 |
container_issue | 4 |
container_start_page | 233 |
container_title | Journal of Analytical Toxicology |
container_volume | 31 |
creator | Bynum, Nichole Poklis, Justin Garside, Diana Winecker, Ruth |
description | Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. Blood concentrations ranged from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg. |
doi_str_mv | 10.1093/jat/31.4.233 |
format | report |
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In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. Blood concentrations ranged from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/31.4.233</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Journal of Analytical Toxicology, 2007, Vol.31 (4), p.233-236</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>786,790,4509,27958</link.rule.ids></links><search><creatorcontrib>Bynum, Nichole</creatorcontrib><creatorcontrib>Poklis, Justin</creatorcontrib><creatorcontrib>Garside, Diana</creatorcontrib><creatorcontrib>Winecker, Ruth</creatorcontrib><title>Postmortem Memantine Concentrations</title><title>Journal of Analytical Toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><description>Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. 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In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. Blood concentrations ranged from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg.</abstract><pub>Oxford University Press</pub><doi>10.1093/jat/31.4.233</doi></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0146-4760 |
ispartof | Journal of Analytical Toxicology, 2007, Vol.31 (4), p.233-236 |
issn | 0146-4760 1945-2403 |
language | eng |
recordid | cdi_istex_primary_ark_67375_HXZ_PSGNDBRD_6 |
source | Oxford University Press Journals; Alma/SFX Local Collection |
title | Postmortem Memantine Concentrations |
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