Postmortem Memantine Concentrations

Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to a...

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Bibliographic Details
Published in:Journal of Analytical Toxicology 2007, Vol.31 (4), p.233-236
Main Authors: Bynum, Nichole, Poklis, Justin, Garside, Diana, Winecker, Ruth
Format: Report
Language:English
Online Access:Get full text
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Summary:Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. Blood concentrations ranged from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/31.4.233