Consensus nomenclature for CD8+ T cell phenotypes in cancer

Whereas preclinical investigations and clinical studies have established that CD8 + T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8 + T cells in cancer is solely attributable to their cyto...

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Bibliographic Details
Published in:	Oncoimmunology 2015-01, Vol.4 (4), p.e998538-e998538
Main Authors:	Apetoh, Lionel, Smyth, Mark J., Drake, Charles G., Abastado, Jean-Pierre, Apte, Ron N., Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H., Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P., Comin-Anduix, Begoña, Coukos, Georges, Dhodapkar, Madhav V., Dranoff, Glenn, Frazer, Ian H., Fridman, Wolf-Hervé, Gabrilovich, Dmitry I., Gilboa, Eli, Gnjatic, Sacha, Jäger, Dirk, Kalinski, Pawel, Kaufman, Howard L., Kiessling, Rolf, Kirkwood, John, Knuth, Alexander, Liblau, Roland, Lotze, Michael T., Lugli, Enrico, Marincola, Francesco, Melero, Ignacio, Melief, Cornelis J., Mempel, Thorsten R., Mittendorf, Elizabeth A., Odun, Kunle, Overwijk, Willem W., Palucka, Anna Karolina, Parmiani, Giorgio, Ribas, Antoni, Romero, Pedro, Schreiber, Robert D., Schuler, Gerold, Srivastava, Pramod K., Tartour, Eric, Valmori, Danila, van der Burg, Sjoerd H., van der Bruggen, Pierre, van den Eynde, Benoît J., Wang, Ena, Zou, Weiping, Whiteside, Theresa L., Speiser, Daniel E., Pardoll, Drew M., Restifo, Nicholas P., Anderson, Ana C.
Format:	Article
Language:	eng
Subjects:	anergy anticancer immunity Cancer CD8 cytotoxicity effector exhaustion IFNγ Life Sciences Medicin och hälsovetenskap Point of View senescence stemness T cells
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Summary:	Whereas preclinical investigations and clinical studies have established that CD8 + T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8 + T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8 + T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8 + T cell immunity, leading to the emergence of dysfunctional CD8 + T cells. The existence of different types of CD8 + T cells in cancer calls for a more precise definition of the CD8 + T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8 + T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8 + T cells in cancer.
ISSN:	2162-4011 2162-402X 2162-402X