Epigenetic modifiers alter the secondary metabolite composition of a plant endophytic fungus, Pestalotiopsis crassiuscula obtained from the leaves of Fragaria chiloensis

The addition of the DNA methyltransferase inhibitor 500 μM 5-azacytidine to the culture medium of a plant endophytic fungus, Pestalotiopsis crassiuscula , obtained from the leaves of Fragaria chiloensis , dramatically altered the profiles of its metabolites and resulted in the isolation of one new c...

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Bibliographic Details

Published in:	Journal of asian natural products research 2014-04, Vol.16 (4), p.412-417
Main Authors:	Yang, Xiao-Long, Huang, Le, Ruan, Xiao-Li
Format:	Article
Language:	eng
Subjects:	Animals Candida albicans - drug effects coumarin Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology DNA DNA methyltransferase (DNMT) DNA Modification Methylases - antagonists & inhibitors endophytes Epigenetics Epigenomics Fragaria - microbiology Fragaria chiloensis Fungi growing media high performance liquid chromatography leaves Metabolites methyltransferases Microbial Sensitivity Tests Molecular Structure nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Pestalotiopsis Pestalotiopsis crassiuscula plant endophytic fungi Plant Leaves - microbiology secondary metabolites Xylariales - chemistry
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