Improvement of water solubility and in vitro dissolution rate of aceclofenac by complexation with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

The present study deals with the inclusion complexation of aceclofenac with β-cyclodextrin by grinding, microwave and spray-drying techniques. A derivative of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, was also subjected to the complexation process with aceclofenac by spray-drying technique. The...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2010-01, Vol.15 (1), p.64-70
Main Authors: Ranpise, Nisharani S., Kulkarni, Nilesh S., Mair, Parth D., Ranade, Arati N.
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
aceclofenac
Animals
Anti-Inflammatory Agents, Non-Steroidal - analysis
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
beta-Cyclodextrins - chemistry
Biological and medical sciences
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Cyclodextrin
Diclofenac - analogs & derivatives
Diclofenac - analysis
Diclofenac - chemistry
Diclofenac - pharmacology
General pharmacology
inclusion complexes
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powder Diffraction
Rats
Solubility
Spectroscopy, Fourier Transform Infrared
spray-drying technique
Water
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Summary:The present study deals with the inclusion complexation of aceclofenac with β-cyclodextrin by grinding, microwave and spray-drying techniques. A derivative of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, was also subjected to the complexation process with aceclofenac by spray-drying technique. The samples were subjected to in-vitro dissolution studies, fourier transform infra-red spectroscopy, differential scanning calorimetry, nuclear magnetic resonance spectroscopy and x-ray diffraction studies. The in-vitro dissolution of aceclofenac-hydroxypropyl-β-cyclodextrin complex was faster as compared to the aceclofenac- β-cyclodextrin complex and aceclofenac alone. Spray-dried aceclofenac-β-cyclodextrin complex were subjected to anti-inflammatory and analgesic activity and showed significant anti-inflammatory and analgesic activity.
ISSN:1083-7450
1097-9867
DOI:10.3109/10837450903002165