Dysregulation of the Protein Tyrosine Kinase LCK in Lymphoproliferative Disorders and in Other Neoplasias

Initially identified as a T-cell specific member of the Src family of protein tyrosine kinases, Lck has become the object of intensive investigations which have revealed a key role for this kinase in the central processes controlling T-cell development, activation, proliferation and survival. Experi...

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Bibliographic Details
Published in:Leukemia & lymphoma 1999-10, Vol.35 (3-4), p.245-254
Main Authors: Majolini, M. Bernardetta, Boncristiano, Marianna, Baldari, Cosimat
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
LCK
Lck protein
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology
lymphoproliferative disorders
Lymphoproliferative Disorders - enzymology
Lymphoproliferative Disorders - genetics
neoplasia
Neoplasms - enzymology
Neoplasms - genetics
protein kinases
Src protein
tyrosine kinase
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Summary:Initially identified as a T-cell specific member of the Src family of protein tyrosine kinases, Lck has become the object of intensive investigations which have revealed a key role for this kinase in the central processes controlling T-cell development, activation, proliferation and survival. Experimental evidence of the oncogenic potential of Lck, together with the identification of defects in the regulation of Lck expression or activity in T-cell leukemias, suggests that dysregulation of Lck might play a role in neoplastic transformation. Here we review the data documenting a potential role for this kinase in the initiation and maintenance of the transformed state in human cancers.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428199909145727