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Malignant Peripheral Nerve Sheath Tumor of the Pancreas with Perineurial Cell Differentiation
The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the...
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| Published in: | Ultrastructural pathology 1998, Vol.22 (3), p.227-231 |
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| Main Authors: | , , , , |
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| cites | cdi_FETCH-LOGICAL-c401t-cd2a0f9ace7fbecdab491ff394faac3e558fbda13c8597ac5ef23c05c33ce09b3 |
| container_end_page | 231 |
| container_issue | 3 |
| container_start_page | 227 |
| container_title | Ultrastructural pathology |
| container_volume | 22 |
| creator | Hirose, Takanori Maeda, Toshiharu Furuya, Keizo Kiyasu, Yoshito Kawasaki, Hideki |
| description | The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis. |
| doi_str_mv | 10.3109/01913129809033473 |
| format | article |
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The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis.</description><identifier>ISSN: 0191-3123</identifier><identifier>EISSN: 1521-0758</identifier><identifier>DOI: 10.3109/01913129809033473</identifier><identifier>PMID: 9793202</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Aged ; basal lamina ; epithelial membrane antigen ; Female ; Humans ; Immunohistochemistry ; malignant peripheral nerve sheath tumor ; Nerve Sheath Neoplasms ; pancreas ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - ultrastructure ; perineurial cell ; Peripheral Nerves - pathology ; Peripheral Nervous System Neoplasms - diagnostic imaging ; Peripheral Nervous System Neoplasms - pathology ; Peripheral Nervous System Neoplasms - ultrastructure ; pinocytotic vesicle ; Tomography, X-Ray Computed</subject><ispartof>Ultrastructural pathology, 1998, Vol.22 (3), p.227-231</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-cd2a0f9ace7fbecdab491ff394faac3e558fbda13c8597ac5ef23c05c33ce09b3</citedby><cites>FETCH-LOGICAL-c401t-cd2a0f9ace7fbecdab491ff394faac3e558fbda13c8597ac5ef23c05c33ce09b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,4043,27956,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9793202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirose, Takanori</creatorcontrib><creatorcontrib>Maeda, Toshiharu</creatorcontrib><creatorcontrib>Furuya, Keizo</creatorcontrib><creatorcontrib>Kiyasu, Yoshito</creatorcontrib><creatorcontrib>Kawasaki, Hideki</creatorcontrib><title>Malignant Peripheral Nerve Sheath Tumor of the Pancreas with Perineurial Cell Differentiation</title><title>Ultrastructural pathology</title><addtitle>Ultrastruct Pathol</addtitle><description>The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis.</description><subject>Aged</subject><subject>basal lamina</subject><subject>epithelial membrane antigen</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>malignant peripheral nerve sheath tumor</subject><subject>Nerve Sheath Neoplasms</subject><subject>pancreas</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - ultrastructure</subject><subject>perineurial cell</subject><subject>Peripheral Nerves - pathology</subject><subject>Peripheral Nervous System Neoplasms - diagnostic imaging</subject><subject>Peripheral Nervous System Neoplasms - pathology</subject><subject>Peripheral Nervous System Neoplasms - ultrastructure</subject><subject>pinocytotic vesicle</subject><subject>Tomography, X-Ray Computed</subject><issn>0191-3123</issn><issn>1521-0758</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAURS0EaofCD2CB5BW7gB0nSqx2Uw30Q2qhEmWJohfnmbhK7OHZadV_j0czQkJVWXlx77l6Poy9k-KjkkJ_ElJLJUvdCi2Uqhr1gq1kXcpCNHX7kq22eZEL6pC9jvFOCFEr0R6wA91oVYpyxX5ew-R-efCJ3yC5zYgEE_-KdI_8-4iQRn67zIF4sDyNyG_AG0KI_MHlaIt4XMhlZo3TxD87a5HQJwfJBf-GvbIwRXy7f4_Yj7Mvt-uL4urb-eX69KowlZCpMEMJwmow2NgezQB9paW1SlcWwCis69b2A0hl2lo3YGq0pTKiNkoZFLpXR-zDbndD4feCMXWziyYfBB7DErsm_1zoqsxFuSsaCjES2m5DbgZ67KTotkq7J0oz834_vvQzDn-JvcOcn-xy522gGR4CTUOX4HEKZCn7cnE7_fz88T94lj6l0QBhdxcW8tnbf477A87emJo</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Hirose, Takanori</creator><creator>Maeda, Toshiharu</creator><creator>Furuya, Keizo</creator><creator>Kiyasu, Yoshito</creator><creator>Kawasaki, Hideki</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Malignant Peripheral Nerve Sheath Tumor of the Pancreas with Perineurial Cell Differentiation</title><author>Hirose, Takanori ; Maeda, Toshiharu ; Furuya, Keizo ; Kiyasu, Yoshito ; Kawasaki, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-cd2a0f9ace7fbecdab491ff394faac3e558fbda13c8597ac5ef23c05c33ce09b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>basal lamina</topic><topic>epithelial membrane antigen</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>malignant peripheral nerve sheath tumor</topic><topic>Nerve Sheath Neoplasms</topic><topic>pancreas</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - ultrastructure</topic><topic>perineurial cell</topic><topic>Peripheral Nerves - pathology</topic><topic>Peripheral Nervous System Neoplasms - diagnostic imaging</topic><topic>Peripheral Nervous System Neoplasms - pathology</topic><topic>Peripheral Nervous System Neoplasms - ultrastructure</topic><topic>pinocytotic vesicle</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirose, Takanori</creatorcontrib><creatorcontrib>Maeda, Toshiharu</creatorcontrib><creatorcontrib>Furuya, Keizo</creatorcontrib><creatorcontrib>Kiyasu, Yoshito</creatorcontrib><creatorcontrib>Kawasaki, Hideki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrastructural pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirose, Takanori</au><au>Maeda, Toshiharu</au><au>Furuya, Keizo</au><au>Kiyasu, Yoshito</au><au>Kawasaki, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant Peripheral Nerve Sheath Tumor of the Pancreas with Perineurial Cell Differentiation</atitle><jtitle>Ultrastructural pathology</jtitle><addtitle>Ultrastruct Pathol</addtitle><date>1998</date><risdate>1998</risdate><volume>22</volume><issue>3</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>0191-3123</issn><eissn>1521-0758</eissn><notes>ObjectType-Case Study-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-1</notes><notes>ObjectType-Article-3</notes><abstract>The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>9793202</pmid><doi>10.3109/01913129809033473</doi><tpages>5</tpages></addata></record> |
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| ispartof | Ultrastructural pathology, 1998, Vol.22 (3), p.227-231 |
| issn | 0191-3123 1521-0758 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_01913129809033473 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Aged basal lamina epithelial membrane antigen Female Humans Immunohistochemistry malignant peripheral nerve sheath tumor Nerve Sheath Neoplasms pancreas Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - pathology Pancreatic Neoplasms - ultrastructure perineurial cell Peripheral Nerves - pathology Peripheral Nervous System Neoplasms - diagnostic imaging Peripheral Nervous System Neoplasms - pathology Peripheral Nervous System Neoplasms - ultrastructure pinocytotic vesicle Tomography, X-Ray Computed |
| title | Malignant Peripheral Nerve Sheath Tumor of the Pancreas with Perineurial Cell Differentiation |
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