Malignant Peripheral Nerve Sheath Tumor of the Pancreas with Perineurial Cell Differentiation

The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the...

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Bibliographic Details
Published in:Ultrastructural pathology 1998, Vol.22 (3), p.227-231
Main Authors: Hirose, Takanori, Maeda, Toshiharu, Furuya, Keizo, Kiyasu, Yoshito, Kawasaki, Hideki
Format: Article
Language:English
Subjects:
Aged
basal lamina
epithelial membrane antigen
Female
Humans
Immunohistochemistry
malignant peripheral nerve sheath tumor
Nerve Sheath Neoplasms
pancreas
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - ultrastructure
perineurial cell
Peripheral Nerves - pathology
Peripheral Nervous System Neoplasms - diagnostic imaging
Peripheral Nervous System Neoplasms - pathology
Peripheral Nervous System Neoplasms - ultrastructure
pinocytotic vesicle
Tomography, X-Ray Computed
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Summary:The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 × 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis.
ISSN:0191-3123
1521-0758
DOI:10.3109/01913129809033473