MEASLES VIRUS: EVIDENCE FOR ASSOCIATION WITH LUNG CANCER

In recent years the frequency of nonsmokers among lung cancer patients has increased to 10% to 15%. The measles virus has rarely been evoked as an etiological agent in malignant tumors and its role in carcinogenesis remains doubtful. It has been suggested that measles virus phosphoprotein may inhibi...

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Bibliographic Details
Published in:Experimental lung research 2009-10, Vol.35 (8), p.701-712
Main Authors: Sion-Vardy, Netta, Lasarov, Irena, Delgado, Bertha, Gopas, Jacob, Benharroch, Daniel, Ariad, Samuel
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Antigens, Viral - analysis
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - virology
Follow-Up Studies
Humans
Immunohistochemistry
measles virus
Measles virus - chemistry
Middle Aged
non-small cell lung cancer
Pirh2
Prognosis
Survival Rate
Tumor Suppressor Protein p53 - analysis
Ubiquitin-Protein Ligases - analysis
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Summary:In recent years the frequency of nonsmokers among lung cancer patients has increased to 10% to 15%. The measles virus has rarely been evoked as an etiological agent in malignant tumors and its role in carcinogenesis remains doubtful. It has been suggested that measles virus phosphoprotein may inhibit ubiquitination of Pirh2, which has been reported to be overexpressed in lung carcinoma and is responsible for degrading the cell cycle regulator p53. The authors conducted a clinicopathological study of newly diagnosed patients with non-small cell lung carcinoma of all stages seen in a 10-year period. Immunohistochemical studies for measles virus antigens, p53, and Pirh2 were performed using the avidin-biotin peroxidase complex. The authors found expression of measles virus antigens in 54 of 65 cases of non-small cell lung carcinoma. This finding is associated with the older age of the patients and with expression of Pirh2. The presence of Pirh2 itself was associated with improved survival.
ISSN:0190-2148
1521-0499
DOI:10.3109/01902140902853176