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Astrocytic pathology in the immune-mediated motor neuron injury
Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an immune-mediated motor neuron injury model, histological, im...
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| Published in: | Amyotrophic lateral sclerosis 2007-01, Vol.8 (4), p.230-234 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c435t-a1c49ce8324b50b28e3a682f72f3ec4898e5c41e3044bb6fe75542c1fbb23a7d3 |
| container_end_page | 234 |
| container_issue | 4 |
| container_start_page | 230 |
| container_title | Amyotrophic lateral sclerosis |
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| creator | Guo, Yansu Liu, Yaling Xu, Lei Wu, Shuyu Yang, Cheng Wu, Dongxia Wu, Hongran Li, Chunyan |
| description | Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an immune-mediated motor neuron injury model, histological, immunohistochemical and ultrastructural studies on astrocytes were carried out. Reactive astrogliosis in spinal cord anterior horn was observed, and the increase of GFAP-positive astrocytes may occur prior to the clinical manifestations. Reactive astrocytes could show pathological changes similar to those of motor neurons, such as swollen mitochondria and dilated endoplasmic reticulum. Of special interest are crystallized inclusions that were frequently observed in the reactive astrocytes in the bovine ventral horn homogenate-immunized anterior horn. The precise nature and origin of these inclusions deserve to be elucidated. |
| doi_str_mv | 10.1080/17482960701278612 |
| format | article |
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On the basis of the establishment of an immune-mediated motor neuron injury model, histological, immunohistochemical and ultrastructural studies on astrocytes were carried out. Reactive astrogliosis in spinal cord anterior horn was observed, and the increase of GFAP-positive astrocytes may occur prior to the clinical manifestations. Reactive astrocytes could show pathological changes similar to those of motor neurons, such as swollen mitochondria and dilated endoplasmic reticulum. Of special interest are crystallized inclusions that were frequently observed in the reactive astrocytes in the bovine ventral horn homogenate-immunized anterior horn. The precise nature and origin of these inclusions deserve to be elucidated.</description><identifier>ISSN: 1748-2968</identifier><identifier>ISSN: 1466-0822</identifier><identifier>EISSN: 1471-180X</identifier><identifier>DOI: 10.1080/17482960701278612</identifier><identifier>PMID: 17653921</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Amyotrophic lateral sclerosis ; Animals ; Astrocytes - metabolism ; Astrocytes - pathology ; Astrocytes - ultrastructure ; astrogliosis ; Disease Models, Animal ; Glial Fibrillary Acidic Protein - metabolism ; Guinea Pigs ; immune ; Male ; Microscopy, Electron, Transmission - methods ; motor neuron ; Motor Neuron Disease - immunology ; Motor Neuron Disease - pathology ; Motor Neuron Disease - physiopathology ; Nerve Degeneration - pathology ; spinal cord</subject><ispartof>Amyotrophic lateral sclerosis, 2007-01, Vol.8 (4), p.230-234</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-a1c49ce8324b50b28e3a682f72f3ec4898e5c41e3044bb6fe75542c1fbb23a7d3</citedby><cites>FETCH-LOGICAL-c435t-a1c49ce8324b50b28e3a682f72f3ec4898e5c41e3044bb6fe75542c1fbb23a7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17653921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Yansu</creatorcontrib><creatorcontrib>Liu, Yaling</creatorcontrib><creatorcontrib>Xu, Lei</creatorcontrib><creatorcontrib>Wu, Shuyu</creatorcontrib><creatorcontrib>Yang, Cheng</creatorcontrib><creatorcontrib>Wu, Dongxia</creatorcontrib><creatorcontrib>Wu, Hongran</creatorcontrib><creatorcontrib>Li, Chunyan</creatorcontrib><title>Astrocytic pathology in the immune-mediated motor neuron injury</title><title>Amyotrophic lateral sclerosis</title><addtitle>Amyotroph Lateral Scler</addtitle><description>Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an immune-mediated motor neuron injury model, histological, immunohistochemical and ultrastructural studies on astrocytes were carried out. Reactive astrogliosis in spinal cord anterior horn was observed, and the increase of GFAP-positive astrocytes may occur prior to the clinical manifestations. Reactive astrocytes could show pathological changes similar to those of motor neurons, such as swollen mitochondria and dilated endoplasmic reticulum. Of special interest are crystallized inclusions that were frequently observed in the reactive astrocytes in the bovine ventral horn homogenate-immunized anterior horn. The precise nature and origin of these inclusions deserve to be elucidated.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Animals</subject><subject>Astrocytes - metabolism</subject><subject>Astrocytes - pathology</subject><subject>Astrocytes - ultrastructure</subject><subject>astrogliosis</subject><subject>Disease Models, Animal</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Guinea Pigs</subject><subject>immune</subject><subject>Male</subject><subject>Microscopy, Electron, Transmission - methods</subject><subject>motor neuron</subject><subject>Motor Neuron Disease - immunology</subject><subject>Motor Neuron Disease - pathology</subject><subject>Motor Neuron Disease - physiopathology</subject><subject>Nerve Degeneration - pathology</subject><subject>spinal cord</subject><issn>1748-2968</issn><issn>1466-0822</issn><issn>1471-180X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKxDAUhoMo3h_AjXTlrpprk6Igw-ANBDcK7kKanjod2mZMUqRvb2QGRARdnQPn-38OH0InBJ8TrPAFkVzRssASEypVQegW2idckpwo_Lqd9nTPE6D20EEIS4wFLSndRXtEFoKVlOyj61mI3tkptjZbmbhwnXubsnbI4gKytu_HAfIe6tZEqLPeReezAUbvhsQsRz8doZ3GdAGON_MQvdzePM_v88enu4f57DG3nImYG2J5aUExyiuBK6qAmULRRtKGgeWqVCAsJ8Aw51VVNCCF4NSSpqooM7Jmh-hs3bvy7n2EEHXfBgtdZwZwY9ASS1Zipf4FKU6CqBAJJGvQeheCh0avfNsbP2mC9Zde_UtvypxuyscqWflObHwm4GoNtEPjfG8-nO9qHc3UOd94M9g2aPZX_-WP-AJMFxfWeNBLN_ohGf7ju0-Pnpp2</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Guo, Yansu</creator><creator>Liu, Yaling</creator><creator>Xu, Lei</creator><creator>Wu, Shuyu</creator><creator>Yang, Cheng</creator><creator>Wu, Dongxia</creator><creator>Wu, Hongran</creator><creator>Li, Chunyan</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Astrocytic pathology in the immune-mediated motor neuron injury</title><author>Guo, Yansu ; Liu, Yaling ; Xu, Lei ; Wu, Shuyu ; Yang, Cheng ; Wu, Dongxia ; Wu, Hongran ; Li, Chunyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-a1c49ce8324b50b28e3a682f72f3ec4898e5c41e3044bb6fe75542c1fbb23a7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amyotrophic lateral sclerosis</topic><topic>Animals</topic><topic>Astrocytes - metabolism</topic><topic>Astrocytes - pathology</topic><topic>Astrocytes - ultrastructure</topic><topic>astrogliosis</topic><topic>Disease Models, Animal</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Guinea Pigs</topic><topic>immune</topic><topic>Male</topic><topic>Microscopy, Electron, Transmission - methods</topic><topic>motor neuron</topic><topic>Motor Neuron Disease - immunology</topic><topic>Motor Neuron Disease - pathology</topic><topic>Motor Neuron Disease - physiopathology</topic><topic>Nerve Degeneration - pathology</topic><topic>spinal cord</topic><toplevel>online_resources</toplevel><creatorcontrib>Guo, Yansu</creatorcontrib><creatorcontrib>Liu, Yaling</creatorcontrib><creatorcontrib>Xu, Lei</creatorcontrib><creatorcontrib>Wu, Shuyu</creatorcontrib><creatorcontrib>Yang, Cheng</creatorcontrib><creatorcontrib>Wu, Dongxia</creatorcontrib><creatorcontrib>Wu, Hongran</creatorcontrib><creatorcontrib>Li, Chunyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Amyotrophic lateral sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Yansu</au><au>Liu, Yaling</au><au>Xu, Lei</au><au>Wu, Shuyu</au><au>Yang, Cheng</au><au>Wu, Dongxia</au><au>Wu, Hongran</au><au>Li, Chunyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astrocytic pathology in the immune-mediated motor neuron injury</atitle><jtitle>Amyotrophic lateral sclerosis</jtitle><addtitle>Amyotroph Lateral Scler</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>8</volume><issue>4</issue><spage>230</spage><epage>234</epage><pages>230-234</pages><issn>1748-2968</issn><issn>1466-0822</issn><eissn>1471-180X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an immune-mediated motor neuron injury model, histological, immunohistochemical and ultrastructural studies on astrocytes were carried out. Reactive astrogliosis in spinal cord anterior horn was observed, and the increase of GFAP-positive astrocytes may occur prior to the clinical manifestations. Reactive astrocytes could show pathological changes similar to those of motor neurons, such as swollen mitochondria and dilated endoplasmic reticulum. Of special interest are crystallized inclusions that were frequently observed in the reactive astrocytes in the bovine ventral horn homogenate-immunized anterior horn. The precise nature and origin of these inclusions deserve to be elucidated.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>17653921</pmid><doi>10.1080/17482960701278612</doi><tpages>5</tpages></addata></record> |
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| ispartof | Amyotrophic lateral sclerosis, 2007-01, Vol.8 (4), p.230-234 |
| issn | 1748-2968 1466-0822 1471-180X |
| language | eng |
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| subjects | Amyotrophic lateral sclerosis Animals Astrocytes - metabolism Astrocytes - pathology Astrocytes - ultrastructure astrogliosis Disease Models, Animal Glial Fibrillary Acidic Protein - metabolism Guinea Pigs immune Male Microscopy, Electron, Transmission - methods motor neuron Motor Neuron Disease - immunology Motor Neuron Disease - pathology Motor Neuron Disease - physiopathology Nerve Degeneration - pathology spinal cord |
| title | Astrocytic pathology in the immune-mediated motor neuron injury |
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