Astrocytic pathology in the immune-mediated motor neuron injury

Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an immune-mediated motor neuron injury model, histological, im...

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Bibliographic Details
Published in:Amyotrophic lateral sclerosis 2007-01, Vol.8 (4), p.230-234
Main Authors: Guo, Yansu, Liu, Yaling, Xu, Lei, Wu, Shuyu, Yang, Cheng, Wu, Dongxia, Wu, Hongran, Li, Chunyan
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Animals
Astrocytes - metabolism
Astrocytes - pathology
Astrocytes - ultrastructure
astrogliosis
Disease Models, Animal
Glial Fibrillary Acidic Protein - metabolism
Guinea Pigs
immune
Male
Microscopy, Electron, Transmission - methods
motor neuron
Motor Neuron Disease - immunology
Motor Neuron Disease - pathology
Motor Neuron Disease - physiopathology
Nerve Degeneration - pathology
spinal cord
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Summary:Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an immune-mediated motor neuron injury model, histological, immunohistochemical and ultrastructural studies on astrocytes were carried out. Reactive astrogliosis in spinal cord anterior horn was observed, and the increase of GFAP-positive astrocytes may occur prior to the clinical manifestations. Reactive astrocytes could show pathological changes similar to those of motor neurons, such as swollen mitochondria and dilated endoplasmic reticulum. Of special interest are crystallized inclusions that were frequently observed in the reactive astrocytes in the bovine ventral horn homogenate-immunized anterior horn. The precise nature and origin of these inclusions deserve to be elucidated.
ISSN:1748-2968
1466-0822
1471-180X
DOI:10.1080/17482960701278612