Impaired nutritional status during intensive chemotherapy in Russian and Norwegian cohorts with acute myeloid leukemia

Intensive chemotherapy is mandatory in curative treatment of acute myeloid leukemia (AML), but whether the nutritional status deteriorates during treatment, is unknown. We therefore prospectively examined anthropometric and biochemical nutritional markers during intensive chemotherapy in 26 Russian...

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Bibliographic Details
Published in:Leukemia & lymphoma 2008-01, Vol.49 (10), p.1916-1924
Main Authors: Iversen, Per Ole, Ukrainchenko, Ekaterina, Afanasyev, Boris, Hulbekkmo, Kristin, Choukah, Amal, Gulbrandsen, Nina, WislØff, Finn, Tangen, Jon-Magnus
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adolescent
Adult
Aged
Anthropometry
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers - analysis
chemotherapeutic approaches
Female
Gonads - physiopathology
Hand Strength
hormones
Humans
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - physiopathology
Male
Middle Aged
Muscle Strength - drug effects
myeloid leukemias and dysplasias
Norway
nutritional status
Nutritional Status - drug effects
Pituitary Gland - physiopathology
prognostication
Quality of Life
Russia
vitamins
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Summary:Intensive chemotherapy is mandatory in curative treatment of acute myeloid leukemia (AML), but whether the nutritional status deteriorates during treatment, is unknown. We therefore prospectively examined anthropometric and biochemical nutritional markers during intensive chemotherapy in 26 Russian and 19 Norwegian AML patients during 9 months from diagnosis. Although the body mass index remained unchanged in both cohorts, hand grip strength and triceps skinfold thickness declined (P < 0.05) during treatment before normalisation at study end. We detected a similar significant, temporary decrease in albumin, transferrin, testosterone and gonadotrophins in both cohorts. Although the fat-soluble vitamins D and E also displayed such a pattern, vitamin A dropped and remained low throughout the study in both cohorts. The Russian patients reported lower global quality of life, more symptoms and more financial concern than the Norwegians. Our data suggest a catabolic metabolism during intensive chemotherapy for AML, leading to impaired nutritional status, hypofunction of the pituitary-gonadal axis and decreased health-related quality of life.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190802339723