THROMBIN GENERATION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA: Effect of Leukemia Immunophenotypic Subgroups

Elevated plasma concentrations of endogenous thrombin generation markers and thrombotic events have been reported in children with leukemia. The aim of this study was to evaluate the effects of cancer and its treatment on thrombin generation (TAT levels) in children with acute lymphoblastic leukemia...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2000, Vol.17 (8), p.667-672
Main Authors: Giordano, Paola, Vecchio, Giovanni Carlo Del, Santoro, Nicola, Arcamone, Giampaolo, Coppola, Brigida, Altomare, Maria, Schettini, Federico, Iolascon, Achille, Mattia, Domenico De
Format: Article
Language:English
Subjects:
Adolescent
All
Biological and medical sciences
Blood Coagulation Tests
Burkitt Lymphoma - drug therapy
Burkitt Lymphoma - immunology
Burkitt Lymphoma - metabolism
Child
Child, Preschool
Children
Female
Follow-Up Studies
Genetic Predisposition to Disease
Hematologic and hematopoietic diseases
Humans
Immunophenotype
Immunophenotyping
Infant
Leukemia-Lymphoma, Adult T-Cell - drug therapy
Leukemia-Lymphoma, Adult T-Cell - immunology
Leukemia-Lymphoma, Adult T-Cell - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Polymorphism, Genetic
Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism
Thrombin - metabolism
Thrombosis - blood
Thrombosis - genetics
Thrombotic Risk
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Summary:Elevated plasma concentrations of endogenous thrombin generation markers and thrombotic events have been reported in children with leukemia. The aim of this study was to evaluate the effects of cancer and its treatment on thrombin generation (TAT levels) in children with acute lymphoblastic leukemia (ALL). The authors evaluated 32 children (23 M, 9 F) aged between 1 and 15 years (mean 6) affected by ALL (immunophenotypic subgroups: 16 common, 7 T, and 9 pre-B type). In all patients TAT levels at onset and after 5-6 doses of L-asparaginase were evaluated. TAT levels were higher in patients both at onset (13.04 +/- 10.90 ng/L) and after the 5-6 doses of L-asp (19.41 +/- 11.05 ng/L) with respect to controls (4 +/- 1 ng/L) (p < .001 and p < .001). TAT levels after 5-6 doses of L-asp were higher than those at onset (p < .001). Factorial ANOVA showed that at onset there was a significant effect of leukemia immunophenotypic subgroups upon TAT levels (p < .05) and no effect of inherited thrombotic risk factors. These results indicate that in children with ALL an important role is played by acquired thrombotic risk factors, among which the indirect cancer procoagulant activity has its importance.
ISSN:0888-0018
1521-0669
DOI:10.1080/08880010050211376