Myeloperoxidase as Inflammatory Marker of Periodontal Disease: Experimental Study in Rats

Rationale: Previous studies have used myeloperoxidase (MPO) as an inflammatory marker to estimate the accumulation of neutrophils in inflamed regions. Objective: The aim of this experimental study was to quantify the levels of MPO related to experimental periodontal disease in rats. Methods: Periodo...

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Bibliographic Details
Published in:Immunological investigations 2009, Vol.38 (2), p.117-122
Main Authors: Gomes, Débora A. S., Pires, Juliana R., Zuza, Elizangela P., Muscara, Marcelo N., Herrera, Bruno S., Spolidorio, Luís C., Toledo, Benedicto E. C., Spolidorio, Denise M. P.
Format: Article
Language:English
Subjects:
Animals
Biomarkers - analysis
Disease Models, Animal
Enzymes
Gingiva - enzymology
Inflammation
Male
Neutrophils - enzymology
Neutrophils - immunology
Periodontal diseases
Periodontitis - diagnosis
Periodontitis - enzymology
Peroxidase
Peroxidase - analysis
Peroxidase - immunology
Rats
Rats, Wistar
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Summary:Rationale: Previous studies have used myeloperoxidase (MPO) as an inflammatory marker to estimate the accumulation of neutrophils in inflamed regions. Objective: The aim of this experimental study was to quantify the levels of MPO related to experimental periodontal disease in rats. Methods: Periodontal disease was induced in a group of rats using placement of a ligature around molar teeth. A group of rats without ligature placement served as a control. Measurements were made on the 3rd, 7th, 15th and 30th day from baseline. Gingival tissues were taken for quantification of MPO levels by ELISA. Results: The rats with induced periodontal disease showed statistically higher MPO levels (p < 0.05) when compared to control rats. A significant increase in the levels of MPO released on days 7 and 30 was observed, with higher levels in the group with induced periodontitis. Conclusion: The levels of MPO were found to be higher in rats with induced periodontal disease, confirming the hypothesis that MPO may serve as an inflammatory marker for periodontitis.
ISSN:0882-0139
1532-4311
DOI:10.1080/08820130802457503