5-Fluorouracil-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(lactide-co-glycolide) polymers: Characterization and drug release

5-Fluorouracil (5-FU), a hydrosoluble anti-neoplastic drug, was encapsulated in microspheres of poly(D,L-lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) polymers using the spray-drying technique, in order to obtain small size microspheres with a significant drug entrapment efficiency. Drug-load...

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Bibliographic Details
Published in:Journal of microencapsulation 2005-09, Vol.22 (6), p.671-682
Main Authors: Blanco, M. D., Sastre, R. L., Teijón, C., Olmo, R., Teijón, J. M.
Format: Article
Language:English
Subjects:
5-Fluorouracil
Antimetabolites, Antineoplastic - administration & dosage
Antimetabolites, Antineoplastic - chemistry
Biological and medical sciences
controlled release
Delayed-Action Preparations
Drug Delivery Systems
Drug Stability
Fluorouracil - administration & dosage
Fluorouracil - chemistry
General pharmacology
Medical sciences
Microscopy, Electron, Scanning
Microspheres
Molecular Weight
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
poly(D,L-lactide)
poly(lactide-co-glycolide)
Polyesters - chemistry
Polyglactin 910 - chemistry
spray-dryer
Temperature
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Summary:5-Fluorouracil (5-FU), a hydrosoluble anti-neoplastic drug, was encapsulated in microspheres of poly(D,L-lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) polymers using the spray-drying technique, in order to obtain small size microspheres with a significant drug entrapment efficiency. Drug-loaded microspheres included between 47 ± 11 and 67 ± 12 µg 5-FU mg−1 microspheres and the percentage of entrapment efficiency was between 52 ± 12 and 74 ± 13. Microspheres were of small size (average diameter: 0.9 ± 0.4-1.4 ± 0.8 µm microspheres without drug; 1.1 ± 0.5-1.7 ± 0.9 µm 5-FU-loaded microspheres) and their surface was smooth and slightly porous, some hollows or deformations were observed in microspheres prepared from polymers with larger Tg. A fractionation process of the raw polymer during the formation of microspheres was observed as an increase of the average molecular weight and also of Tg of the polymer of the microspheres. The presence of 5-FU did not modify the Tg values of the microspheres. Significant interactions between the drug and each one of the polymers did not take place and total release of the included drug was observed in all cases. The time needed for the total drug release (28-129 h) was in the order PLA > PLGA 75 25 > PLGA 50 50. A burst effect (17-20%) was observed during the first hour and then a period of constant release rate (3.52 ± 0.82-1.46 ± 0.26 µg 5-FU h−1 per milligram of microspheres) up to 8 or 13 h, depending on the polymer, was obtained.
ISSN:0265-2048
1464-5246
DOI:10.1080/02652040500161990