Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer From Adjacent Normal Tissue

Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled person...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2021-12, Vol.68 (12), p.3554-3563
Main Authors: Pal, Uttam M., Nayak, Ashika, Medisetti, Tejaswi, Gogoi, Gayatri, Shekhar, Himanshu, Prasad, M.S.N., Vaidya, Jayant S., Pandya, Hardik J.
Format: Article
Language:English
Subjects:
Acoustic attenuation
Acoustic measurements
Attenuation coefficients
Biomedical optical imaging
Biopsy
biopsy tissue
Breast cancer
Diagnosis
Fibroadenoma
Histopathology
label-free
Lumpectomy
Near-infrared spectroscopy
Optical attenuators
Optical imaging
Scattering coefficient
Spectra
Spectroscopy
Statistical analysis
Tissues
Ultrasonic attenuation
Ultrasonic imaging
Ultrasonic testing
Ultrasonic variables measurement
Ultrasound
ultrasound attenuation
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled personnel. Method: We describe a Hybrid Spectral-IRDx - a combination of the previously reported Spectral-IRDx tool with multimodal ultrasound and NIR spectroscopy techniques. We show how this portable, cost-effective, minimal-contact tool could provide rapid diagnosis of cancer using formalin-fixed (FF) and deparaffinized (DP) breast biopsy tissues. Results: Using this new tool, measurements were performed on cancerous/fibroadenoma and its adjacent normal tissues from the same patients (N = 14). The acoustic attenuation coefficient (α) and reduced scattering coefficient (µ' s ) (at 850, 940, and 1060 nm) for the cancerous/fibroadenoma tissues were reported to be higher compared to adjacent normal tissues, a basis of delineation. Comparing FF cancerous and adjacent normal tissue, the difference in µ' s at 850 nm and 940 nm were statistically significant ( p = 3.17e-2 and 7.94e-3 respectively). The difference in α between the cancerous and adjacent normal tissues for DP and FF tissues were also statistically significant ( p = 2.85e-2 and 7.94e-3 respectively). Combining multimodal parameters α and µ' s (at 940 nm) show highest statistical significance ( p = 6.72e-4) between FF cancerous/fibroadenoma and adjacent normal tissues. Conclusion: We show that Hybrid Spectral-IRDx can accurately delineate between cancerous and adjacent normal breast biopsy tissue. Significance: The results obtained establish the proof-of-principle and large-scale testing of this multimodal breast cancer diagnostic platform for core biopsy diagnosis.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2021.3077582