Design and Development of Point of Care Test and Optical Reader for Early Screening of Kidney Related Disorder

Low-cost, paper-based colorimetric assays for early screening of albumin, creatinine and their ratio are developed. The developed methods are non-invasive and require only 10\ \mu\mathrm{l} of the urine sample. A reflectance-based optical reader is also developed for the quantification of the albumi...

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Bibliographic Details
Main Authors: Shivhare, Pankaj, Mohla, Satyam, Dube, Tejal, Verma, Alok, Srivastava, Rohit
Format: Conference Proceeding
Language:English
Online Access:Request full text
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Summary:Low-cost, paper-based colorimetric assays for early screening of albumin, creatinine and their ratio are developed. The developed methods are non-invasive and require only 10\ \mu\mathrm{l} of the urine sample. A reflectance-based optical reader is also developed for the quantification of the albumin and creatinine. The developed method is based on spot-urine testing, which is advantageous when compared to the conventional 24-hr urine collection. The detection range of albumin and creatinine assays is 10-150 mg/dL and 25-400 mg/dL, respectively. The developed assays and optical reader were tested with the chronic kidney diseased patient's samples at KEM Hospital, Mumbai.
ISSN:2159-6972
DOI:10.1109/NANOMED49242.2019.9130619